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NEUROLOGY 1987;37:715
© 1987 American Academy of Neurology

Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417

R. J. Hawley, MD, R. Kratz, MD, R. R. Goodman, MD, C. B. McCutchen, MD, M. Sirdofsky, MD and P. A. Hanson, MD

Department of Neurology (Drs. Kratz, Sirdofsky, and Hanson), Georgetown University Hospital, and the Neurology Service (Drs. Hawley, Goodman, and McCutchen), DC VA Medical Center, Washington, DC.

Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-1417, IM twice a day for 1 month in an open-label trial, produced no objective improvement of strength in nine patients with ALS. No patient entered the double-blind, placebo-controlled phase of the trial.

Address correspondence and reprint requests to Dr. Hawley, 688/127, DC VA Medical Center. 50 Irving Street, NW, Washington, DC 20422.

Supported by the Veterans Administration.

Received April 4, 1986. Accepted for publication in final form August 5, 1986.




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[Abstract] [PDF]


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