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Hematogenous origin of brain macrophages

A case report

Departments of Pathology (Drs. Casanova, Troncoso, and Price), Neurology (Drs. Troncoso and Price), and Neuroscience (Dr. Price), Neuropathology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, MD.

Del Rio-Hortega believed that phagocytic cells in the CNS arise from microglia; however, recent autoradiographic studies have suggested a hematogenous origin for brain macrophages. To clarify this issue, we studied a young man with acute lymphoblastic leukemia and a peripheral white blood cell count of 22/mm³ who had an embolic brain infarct 2 weeks before he died. Macrophages were scarce within the lesion, suggesting that the principal phagocytic cell is hematogenous.

Address correspondence and reprint requests to Dr. Casanova, Neuropathology Laboratory, 509 Pathology Building, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205.

Supported by grants from the US Public Health Service (NIH NS 07179, NS 20471, and AG 05146). Dr. Troncoso is a recipient of NINCDS Teacher-Investigator Development Award (NIH NS 00799).

Accepted for publication October 15, 1985.