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NEUROLOGY 1986;36:698
© 1986 American Academy of Neurology

Neurologic sequelae of chronic solvent vapor abuse

Joseph T. Hormes, MD, Christopher M. Filley, MD and Neil L. Rosenberg, MD

Department of Neurology. University of Colorado, School of Medicine, Denver General Hospital, Denver, CO.

Neurologic abnormalities were seen in 13 of 20 patients with a history of chronic solvent vapor (primarily toluene) abuse for 2 or more years. The patients were evaluated after an abstinence period of at least 4 weeks, to avoid neurologic effects of acute intoxication. Neurologic signs included cognitive (60%), pyramidal (50%), cerebellar (45%), and brainstem/ cranial nerve (25%) findings. Eight of nine CTs revealed diffuse atrophy of cerebral hemispheres, cerebellum, and brainstem. BAERs were abnormal in three of four patients, and EEG abnormalities were seen in three of seven patients. Chronic exposure to solvent vapor may cause persistent neurologic impairment.

Address correspondence and reprint requests to Dr. Rosenberg, Department of Neurology, Denver General Hospital, 777 Bannock Street, Denver, CO 80204–4507.

Accepted for publication September 20, 1985.




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