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Autoradiographic localization of thyr tropin releasing hormone receptors in human brain

Departments of Biology (Dr. Manaker), Pharmacology (Drs. Eichen, Winokur, and Rainbow), Psychiatry (Dr. Winokur), and Division of Neuropathology (Dr. Rhodes), University of Pennsylvania, Philadelphia, P A.

We used quantitative autoradiography to localize thyrotropin releasing hormone (TRH) receptors in human brain. Highest concentrations of TRH receptors were localized within the cortical, basal, and lateral nuclei of the amygdala and the molecular layer of the hippocampus. Low levels were found in the cortex, diencephalon, and basal ganglia. The radioligand bound with similar affinity and pharmacology to pituitary gland as to brain. These data suggest that authentic TRH receptors in the hippocampus and amygdala may mediate the putative effects of TRH on the human brain.

Address correspondence and reprint requests to Dr. Manaker, Department of Pharmacology/G-3, University of Pennsylvania, Philadelphia, PA 19104.

Portions of this work were completed by the first author in partial fulfillment of the PhD degree from the University of Pennsylvania. Supported by Medical Scientist Training Program NIH 5-T32-GM07170 to S.M.; NIMH Research Scientist Development Award MH00044 and NIH NS 18332 to A.W.; 2-T32-NS07064 to C.H.R.; and NS 19597, NS 20006, and fellowships from the Alfred P. Sloan Foundation and the Esther A. and Joseph Klingenstein Fund to T.C.R.

Accepted for publication September 20, 1985.

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