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NEUROLOGY 1986;36:618
© 1986 American Academy of Neurology

Myasthenia gravis

Stimulation of antireceptor autoantibodies by autoreactive T cell lines

Reinhard Hohlfeld, MD, Inge Kalies, PhD, Birgit Kohleisen, PhD, Kurt Heininger, MD, PhD, Bianca Conti-Tronconi, MD and Klaus V. Toyka, MD

Department of Neurology (Drs. Hohlfeld, Heininger. and Toyka). University of Düsseldorf. and the Institute for Clinical Immunology (Drs. Kalies and Kohleisen), University of Erlangen, West Germany; and the Division of Chemistry (Dr. Conti-Tronconi). California Institute of Technology, Pasadena, CA.

We studied autoreactive acetylcholine receptor (AChR)-specific T cell lines from two patients with myasthenia gravis. Anti-AChR auto antibody production by peripheral blood mononuclear cells (PBM) from the donors of the T cell lines was measured with an enzyme-linked immunoadsorbent assay, using purified human AChR as antigen. Freshly isolated PBM produced barely detectable amounts of anti-AChR autoantibodies. If, however, auto logous AChR-specific T cells were added to the cultures, the production of anti-AChR auto antibodies, and of total IgM and IgG, was markedly stimulated, depending on the number of T line cells and on the amount of AChR present in the cultures. AChR-specific functional helper Tlymphocytes may have a role in the immunoregulation of myasthenia gravis.

Address correspondence and reprint requests to Dr. Hohlfeld. Neurologische Universitätsklinik, Moorenstrasse 5,4000 Düsseldorf 1, West Germany.

Supported by the Deutsche Forschungsgemeinschaft, SFB 200, B5; Ka 325/8.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX. April 1985.

Accepted for publication October 1, 1985.




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R. Hohlfeld
Myasthenia gravis
Neurology, February 1, 1999; 52(3): 443 - 443.
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