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Function of dopamine receptors in Parkinson's disease

Prolactin responses

Department of Neurology, University of Turku, Finland.

In 64 patients with Parkinson's disease (PD), the basal level of prolactin (PRL) was normal. Bromocriptine (BCT) caused a significant suppression of PRL in all parkinsonian patients and controls. When given after BCT treatment, thyrotropin-releasing hormone (TRH) induced a significantly lower PRL rise in recent-onset parkinsonian patients than in controls or advanced patients. In advanced parkinsonian patients with daily fluctuations in disability, the corresponding TRH-induced PRL response was significantly higher than in controls. In advanced parkinsonian patients without fluctuations, the PRL response to TRH was almost the same as in controls.

Address correspondence and reprint requests to Dr. Laihinen, Department of Neurology, University of Turku, Turku, Finland.

Accepted for publication July 26, 1985.