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NEUROLOGY 1986;36:1330
© 1986 American Academy of Neurology

Effects of amyotrophic lateral sclerosis serum on cultured chick spinal neurons

Patrick Doherty, John G. Dickson, Thomas P. Flanigan, Peter G.E. Kennedy and Frank S. Walsh

Departments of Neurochemistry and Clinical Neurology, Institute of Neurology, Queen Square, London, UK.

We used a quantitative immunoassay to examine the effects of human serum and immunoglobulins on neurofilament protein expression in cultures of chick spinal neurons. Compared with cultures grown in the presence of serum from healthy controls or patients with other neurologic disorders, ALS serum lowered the level of neurofilament proteins. Effects were similar with or without muscle-derived neurotrophic factors; there was no specificity for motor neurons. No neurotoxic activity was found in immunoglobulin fractions, and there was no evidence of circulating antibodies that might neutralize muscle-derived neurotrophic factors or induce cytolysis of spinal neurons.

Address correspondence and reprint requests to Dr. Doherty, Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG, UK.

Supported by the Motor Neurone Disease Association (UK). ALSSOA, and the Lister Wolfson Research Project in Motor Neuron Disease.

Accepted for publication February 16, 1986.




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