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NEUROLOGY 1985;35:1152
© 1985 American Academy of Neurology

Reversible chronic cerebellar ataxia after phenytoin intoxication

Possible role of cerebellum in cognitive thought

M. I. Botez, MD, Jacqueline Gravel, MS, Ezzedine Attig, MD and Jean-Lorrain Vézina, MD

Laboratory of Neuropsychology, Clinical Research Institute of Montreal (Drs. Botez and Gravel); and the Departments of Neurology (Dr. Attig) and Radiology (Dr. Vézina), Hótel-Dieu Hospital, Montréal, Québec, Canada.

Reversible chronic cerebellar ataxia followed phenytoin treatment in two epileptic women. Cerebellar ataxia in both patients and axonal polyneuropathy in one patient were improved after administration of thiamine alone or with folate. In one patient, some specific behavioral functions improved. However, recovery could have been spontaneous.

Address correspondence and reprint requests to Dr. Botez, Clinical Research Institute of Montreal, 110 Pine Avenue, West. Montréal, Québec, Canada. H2W IR7.

Supported by the Fonds de la Recherche en Santé du Québec (to M. I. B.) and grants from the Jeanne-Mance Foundation (to J. L. V. and M. I. B.).

Accepted for publication December 4, 1984.




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