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Progressive dementia, visual deficits, amyotrophy, and microinfarcts

Departments of Neurology (Drs. Kaplan, Katzman, and Fuld) and Neuropathology (Dr. Horoupian), Albert Einstein College of Medicine; and the Department of Neurology (Dr. Mayeux) and Division of Neuropatholngy (Dr. Hays), Columbia Presbyterian Medical Center, New York, NY.

Data from three patients and 22 previously reported cases suggest that cerebral microinfarction causes a recognizable clinical syndrome. All cases present with stroke, followed by progressive dementia and often with visual field deficits, peripheral vascular disease, and signs of motor neuron dysfunction. The average age at onset is 45, and most patients have been men. Many patients have had valvular or ischemic heart disease; in one of our cases, mitral stenosis caused embolic microinfarcts.

Address correspondence and reprint requests to Dr. Kaplan, Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, FORCHH. G-9, Bronx, NY 10461.

Accepted for publication October 14, 1984

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