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NEUROLOGY 1985;35:625
© 1985 American Academy of Neurology

Cerebral amyloid angiopathy

G. Rees Cosgrove, MD, Richard Leblanc, MSc, MD, FRCS(C), Kathleen Meagher-Villemure, MD and Romeo Ethier, MD

Departments of Neurosurgery, Neuropathology, and Neuroradiology, Montreal Neurological Hospital and McGill University, Montreal, Quebec, Canada.

We studied 24 patients with autopsy-proven cerebral amyloid angiopathy. Eight patients were demented or had some other medical problem and died of pneumonia or systemic disease. Sixteen patients died of intracranial hemorrhage. Amyloid was found in cortical arteries and arterioles of all patients. CT showed diffuse atrophy in demented patients and intracerebral hematomas in the others. The location and size of the hematoma, with cortical and subarachnoid extension, help to differentiate amyloid angiopathy from other causes of intracranial hemorrhage in the elderly.

Address correspondence and reprint requests to Dr. Leblanc, Montreal Neurological Hospital, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

Accepted for publication August 29, 1984.




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