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Treatment of seizures with medroxyprogesterone acetate

Preliminary report

From the Department of Neurology, Yale University School of Medicine, New Haven, CT. and the Epilepsy Center, VA Medical Center, West Haven, CT (Dr. Mattson, Ms. Cramer, and Ms. Siconolfi), and the Department of Internal Medicine (Dr. Caldwell), Yale University School of Medicine, New Haven, CT.

Medroxyprogesterone acetate (MPA), a synthetic progesterone, was added to the antiepileptic drug regimen of 14 women who had uncontrolled seizures. Of the 11 women who developed amenorrhea, 7 reported fewer seizures during MPA therapy. Overall reductions in seizure frequency averaged 30% (n = 11), declining from a baseline 8.3 ± 5.8 seizures per month to 5.1 ± 4.1 seizures per month (p = 0.02). No serious side effects were encountered, but spotting was common. These preliminary data suggest further evaluation of MPA for catamenial seizures.

Address correspondence and reprint requests to Dr. Mattson, Epilepsy Center, VA Medical Center-127, West Haven, CT 06516.

Supported by NIH Grant NS06208 and the Veterans Administration Medical Research Service.

Accepted for publication January 26,1984.

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