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NEUROLOGY 1984;34:1182
© 1984 American Academy of Neurology

Antibody to acetylcholine receptor in myasthenia gravis

Production by lymphocytes from thymus or thymoma

Yoshitaka Fujii, MD, Yasumasa Monden, MD, Kazuya Nakahara, MD, Jumpei Hashimoto, MD and Yasunaru Kawashima, MD

From the First Department of Surgery, Osaka University Medical School, Osaka, Japan.

In 13 of 17 myasthenic patients without thymoma and all 7 patients with thymoma, thymic lymphocytes produced antibody to acetylcholine receptor (AChR). Lymphocytes from the thymoma itself did not produce AChR antibody except in one patient. The rate of antibody production was higher in patients without thymoma than in patients with thymoma (32.5 and 3.9 fmol/106 cells/week, respectively). The rate of antibody production was related to the serum titer of AChR antibody (r = 0.7, p < 0.001). Enrichment of B cells using a nylon wool column increased the rate of antibody production by thymic lymphocytes 1.3- to 8.0-fold.

Address correspondence and reprint requests to Dr. Fujii, First Department of Surgery, Osaka University Medical School, 1-1-50 Fukushima Osaka, 553 Japan.

Supported in part by grants from the Ministry of Education, Science and Culture and by the Ministry of Health and Welfare of Japan.

Accepted for publication January 4, 1984.




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