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Lymphocytapheresis in chronic progressive multiple sclerosis

Immunologic and clinical effects

From the Multiple Sclerosis Clinical and Research Unit, Division of Neurology, Department of Medicine, Brigham and Women's Hospital; the Department of Neuroscience and Transfusion Service. Children's Hospital Medical Center; and Harvard Medical School, Boston, MA.

We studied the effects of lymphocytapheresis in five patients with chronic progressive MS. Ten lymphocytapheresis treatments were given in 2 weeks, followed by 1 treatment every 2 weeks for 2 to 6 months. Four of five patients had a fall in the circulating lymphocyte count during the initial treatment, and in three patients a modest lymphopenia was sustained with maintenance therapy. In patients with abnormal T4:T8 ratios, no improvement in the T4:TS ratio occurred. There was no apparent clinical effect in this pilot study.

Address correspondence and reprint requests to Dr. Hauser. Multiple Sclerosis Clinical and Research Unit, Neurology Division, Brigham and Women's Hospital, Boston, MA 02116.

Supported by a grant from the National Institutes of Health (NS-17182). Dr. Hauser is a Postdoctoral Fellow of the National Multiple Sclerosis Society.

Accepted for publication November 18, 1983.

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