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Poliovirus infection of cyclophosphamide-treated mice results in persistence and late paralysis

II. Virologic studies

From The Les Turner ALS Research Laboratory, Department of Neurology, Northwestern University Medical School.

An attenuated human poliovirus infection of cyclophosphamide (CY) -treated mice resulted in a persistent CNS infection. Persistence in asymptomatic animals occurred in 46% of CY-treated mice but in only 3% of untreated animals, and was confined primarily to the brain. Virus replication in the brain peaked by day 3 for all inoculum dilutions, but was lower with diluted virus. High virus titers in the spinal cord were found only in paralyzed animals and occurred late in the infection following inoculation of diluted virus. Thus, the level of virus replication in the brain was directly related to the amount of virus inoculated, and was correlated with the rapidity of virus transit to the spinal cord and the incubation time to paralysis.

Address correspondence and reprint requests to Dr. Jubelt, Department of Neurology, Northwestern University Medical School, 308 East Chicago Avenue, Chicago. IL 60611.

This work was supported by a Basic Research Grant from the Muscular Dystrophy Association, grant RR-05370 from the US Public Health Service, National Institutes of Health. and Dr. Jubelt's Teacher-Investigator Development Award (no. 5-KO7NS00573) from the NINCDS, US Public Health Service.

Presented in part at the thirty-fourth Annual Meeting of the American Academy of Neurology, Washington, DC, April 1982.

Accepted for publication July 28, 1983.