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The significance of carotid stenosis or ulceration

From The University of Texas Medical School at Houston, Houston, TX.

Data from the medical treatment group of the Aspirin in TIA study were reviewed, and prospective analysis of patients with asymptomatic bruits was performed to see whether carotid stenosis (0 to 49% or 50 to 99%) or ulceration produced an increased risk of ipsilateral TIA or infarct. In symptomatic arteries, > 50% stenosis without ulceration implied a higher risk of subsequent symptoms. Ulceration was associated with an increased risk only in nonstenotic vessels. Lesion anatomy was not related to outcome in asymptomatic arteries, and the incidence of cerebral infarct was low. Factors other than anatomy must play a large role in determining subsequent risk.

Address correspondence and reprint requests to Dr. Grotta, University of Texas Medical School, 6431 Fannin, Houston, TX 77030.

The AITIA Study was supported by NHLBI grant No. HL-14340-03 to the central registry and separate grants to the participating institutions.

Accepted for publication July 26, 1983.

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