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Intracerebral masses in patients with intractable partial epilepsy

From the Departments of Neurology and Surgery (Neurosurgery). Yale University School of Medicine, New Haven, and Veterans Administration Medical Center, West Haven, CT.

One hundred ninety patients were considered for surgical treatment of uncontrolled partial seizures. Twenty-seven (15%) had intracranial mass lesions detected during preoperative evaluation. Seizures were present for a mean of 10 years. Sixty percent of the patients had prior negative radiologic studies. The lesions included 19 neoplasms and 8 non-neoplastic structural (non-atrophic) lesions. Refractory simple partial seizures and a changing neurologic examination were more commonly associated with neoplasms. Treatment included biopsy and radiation, mass resection, or subtotal lobectomy. Although any form of treatment gave better seizure control, patients undergoing subtotal lobectomy had more than 95% reduction in seizures.

Address correspondence and reprint requests to Dr. Spencer, Section of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

Accepted for publication July 21, 1983.

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