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NEUROLOGY 1984;34:393
© 1984 American Academy of Neurology

ALS and heavy metals

A pilot case-control study

Rita A. Roelofs-Iverson, RN, Donald W. Mulder, MD, Lila R. Elveback, PhD, Leonard T. Kurland, MD, DrPH and Craig A. Molgaard, PhD

From the Departments of Neurology, and Medical Statistics and Epidemiology, Mayo Clinic and Foundation, Rochester, MN.

We conducted a case-control study of suspected risk factors for ALS among referral patients seen at the Mayo Clinic. Responses to questions about demographic factors, diet, medical history, travel, infectious disease, and other variables were similar in ALS patients and controls. In all but a few items, the responses of the cases and controls did not differ significantly. A significant level of shared exposure to an exogenous agent or environmental insult among cases was noted mainly for heavy metals.

Address correspondence and reprint requests to Dr. Kurland, Mayo Clinic, 200 First Street SW, Rochester, MN 55901.

This research supported in part by the St. Gerard Foundation of Clearwater, FL, and by Research Grants GM-14231 and NS-17750 from the National Institutes of Health, Public Health Service, Bethesda, MD.

Accepted for publication June 24, 1983.




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