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CSF ß-endorphin and the severity of pain

From the Departments of Neurology (Drs. Cleeland and Shacham), Pharmacology (Dr. Dahl), and Radiology (Dr. Orrison), Health Sciences Center, University of Wisconsin, Madison, WI.

ß-endorphin-like immunoreactivity (iß-EP) was measured in the CSF at myelography of 24 patients suspected of vertebral disk disease. Patients made several ratings of mood and pain for the 24 hours preceding myelography. Composite scores for pain, negative mood, and positive mood were derived by factor analysis. Pain Factor scores were negatively correlated with iß-EP (r = –0.59, p < 0.001), indicating a possible role for iß-EP in the perception of the severity of pain. No significant correlation was shown between Positive or Negative Mood Factor scores and CSF iß-EP. A physiologic indicator of pain severity is discussed.

Address correspondence and reprint requests to Dr. Cleeland, H6/530,600 Highland Avenue, Madison, WI 53792.

This project was funded in part by NCI grant CA 26582 and by grant CA 16405 awarded to the Wisconsin Clinical Cancer Center.

Accepted for publication June 15, 1983.