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New antigen for antibody detect ion in myasthenia gravis

From the CNR Center of Cytopharmacology, Department of Pharmacology, University of Milano (Drs. Gotti and Clementi), and Istituto Neurologico "C. Besta" (Dr. Mantegazza), Milano, Italy.

We assayed anti-acetylcholine receptor (AChR) antibodies in 61 myasthenic patients using human and fetal calf muscle AChR as antigen. Anti-AChR antibodies were detected in 85% of patients with human AChR and in 80% with fetal calf AChR. In 27 patients, the titers detected with fetal calf AChR were higher than those obtained with human AChR. Titers with different fetal calf AChRpreparations were reproducible. Fetal calf AChR is a suitable antigen for immunologic analysis of myasthenic patients.

Address correspondence and reprint requests to Dr. Gotti, CNR Center of Cytopharmacology, Department of Pharmacology, University of Milan, via Vanvitelli, 32 — 20129 Milano, Italy.

This work was supported by the National Research Council (CNR) — Progetto Finalizzato "Medicina Preventiva e Riabilitativa."

Accepted for publication June 14, 1983.

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