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NEUROLOGY 1984;34:357
© 1984 American Academy of Neurology

Fulminant polyneuritis after overdose of disulfiram and ethanol

John F. Rothrock, MD, Peter C. Johnson, MD, Sharon M. Rothrock and Richard Merkley

From the Department of Neurology, University of California Medical Center, San Diego, CA (Dr. Rothrock), Division of Neuropathology, Arizona Health Sciences Center (Dr. Johnson), University of Arizona School of Medicine (Ms. Rothrock, Mr. Merkley) Tucson, AZ.

A 39-year-old woman developed a severe sensorimotor polyneuritis after simultaneous ingestion of ethanol and disulfiram in high doses. The disorder was similar to other cases of disulfiram neuropathy, but was acute and more severe. Disulfiram can cause a fulminant polyneuropathy that is not always benign and reversible.

Address correspondence and reprint requests to Dr. Rothrock, Department of Neurology, University of California Medical Center, 225 Dickinson Street, San Diego, CA 92103.

Accepted for publication June 13, 1983.






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