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NEUROLOGY 1984;34:310
© 1984 American Academy of Neurology

HLA-linked complement markers in Alzheimer's and Parkinson's disease

C4 variant (C4B2) a possible marker for senile dementia of the Alzheirner type

Christoph Nerl, Richard Mayeux and Geoffrey J. O'Neill

From the Departments of Pathology and Neurology, Columbia University College of Physicians and Surgeons, New York, NY.

We determined the gene frequencies for the alleles of the HLA-linked complement markers C2, properdin factor B (BF), C4A (Rodgers) and C4B (Chido), and the red cell enzyme glyoxalase-I in 38 unrelated patients with senile dementia of the Alzheimer type, 42 patients with idiopathic Parkinson's disease, and 59 unaffected, aged matched control blood donors. In senile dementia of the Alzheimer type and in Parkinson's disease, no significant difference was found in the gene frequencies of alleles at either the BF, C2, or GLO-I locus compared with those of age matched controls. In senile dementia of the Alzheimer type, a striking increase in the frequency of the rare C4B locus allele, C4*B2, was apparent, resulting in the high relative risk of RR = 8.8 (p < 0.0001) for this disorder.

Address correspondence and reprint requests to Dr. Mayeux, Neurological Institute, 710 West 168th Street, New York, NY 10032.

Support for this research was provided by National Institutes of Health awards to Dr. O'Neill (AI-19057) and Dr. Mayeux (AG02802). Dr. Nerl is a recipient of a fellowship given by the German Academic Exchange Service/NATO.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April, 1983.

Accepted for publication June 14, 1983.






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