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"Killer" cells in Duchenne disease

Ultrastructural study

From the Department of Neurology (Dr. Fidziaska), Medical School, Warsaw, Poland, the Department of Neuropathology (Dr. Goebel and Ms. Kosswig), University of Gottingen, Gottingen, and the Department of Human Genetics (Dr. Burck), University of Hamburg, Hamburg, Federal Republic of Germany.

Two fetuses at risk for X-linked recessive Duchenne muscular dystrophy and five affected boys were examined by electronmicroscopy. In all cases, numerous activated lymphocytes were found in different stages of invasion in muscle cells. Characteristic aggressor-muscle cell interactions were manifest by successive phases of cell-to-cell adherence and muscle cell destruction. Cell-mediated cytolysis may play an important role in the pathogenesis of Duchenne muscular dystrophy.

Address correspondence and reprint requests to Dr. Fidziahska, Akademia Medyczna w Warszawie, Klinika Neurologiczna, ul. Oczki 6, O2-007 Warszawa, Poland.

These studies were financially supported by the "Stiftung Volkswagenwerk" Az. I/36303.

Accepted for publication June 14, 1983.