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NEUROLOGY 1984;34:276
© 1984 American Academy of Neurology

Enhanced regional uptake of 2-deoxy-D- [14C] glucose in focal herpes simplex type 1 encephalitis

Autoradiographic study in the rat

Yutaka Saito, MD and Richard W. Price, MD

From the George C. Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY.

We used the 2-deoxy-D-[14C]glucose (14C-DG) quantitative autoradiographic method to assess regional glucose metabolism in rats with focal herpes simplex virus type 1 (HSV-1) encephalitis. High 14C-DG uptake was detected in infected brain structures of both immunocompetent and immunosuppressed animals, likely as a result of increased glucose utilization by infected glia and neurons. Inflammatory infiltrates did not show augmented 14C-DG tissue uptake, and indeed regional isotope uptake declined in the later stages of infection as viral replication waned and necrosis developed. 14C-DG uptake was also depressed in uninfected brain regions that received afferents from the infected visual pathway.

Address correspondence and reprint requests to Dr. Price, Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Supported by US Public Health Service Research Grant No. NS 19048 and the Memorial Sloan-Kettering Cancer Center Neurology Service Fund. Dr. Price is an Irma T. Hirschl Career Scientist Awardee, and Dr. Saito is a Visiting Fellow from the Tokyo Medical College.

Presented at the thirty-fourth Annual Meeting of the American Academy of Neurology, Washington, DC, April, 1982.

Accepted for publication June 13, 1983.






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