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Cerebrospinal fluid GABA levels in children with infantile spasms

From the Department of Pediatrics (Drs. Ito and Mikawa) and Pharmacology (Dr. Taniguchi), Faculty of Medicine, Kyoto University, Kyoto, Japan.

The mean CSF GABA level in 22 children with infantile spasms was significantly lower than in 35 controls. There was no significant difference between the CSF GABA levels in untreated children and those treated with anticonvulsants, or between uncontrolled and temporarily controlled patients. After treatment with ACTH, CSF GABA levels were lower than before treatment, and seizures disappeared. Brain GABAergic neuronal function may be disturbed in children with infantile spasms, but the decreased CSF GABA level does not directly correlate with the seizures of infantile spasms.

Address correspondence and reprint requests to Dr. Ito, Department of Pharmacology & Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1W5, Canada.

This study was supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No. 56770464).

Accepted for publication May 23, 1983.

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