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NEUROLOGY 1984;34:215
© 1984 American Academy of Neurology

Cranial dystonia

Double-blind crossover study of anticholinergics

John G. Nutt, MD, John P. Hammerstad, MD, Pat de Garmo, ANP and Julie Carter, ANP

From the Department of Neurology, Oregon Health Sciences University, Portland, OR.

In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishable in the other eight patients except for the higher incidence of central and peripheral anticholinergic side effects with trihexyphenidyl.

Address correspondence and reprint requests to Dr. Nutt, Department of Neurology (L-226), Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201.

Accepted for publication May 3, 1983.






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