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NEUROLOGY 1984;34:208
© 1984 American Academy of Neurology

Effect of specific antibodies on acetylcholine receptor turnover

Increased degradation controls low density of cell surface receptor

E. Sher and F. Clementi

From the Department of Pharmacology, University of Milan and CNR Center of Cytopharmacology, Milan, Italy.

BC3H-1 cells express surface nicotinic receptors. We treated these cells with pooled serum from myasthenic patients. After 5 hours, the number of surface receptors decreased to one-half of baseline and remained at this low level for at least 72 hours. The rate of receptor degradation was increased by myasthenic serum, but the synthesis of new receptors was unaffected. The regulation of the number of surface nicotinic receptors is thus mediated by an accelerated internalization of the receptor.

Address correspondence and reprint requests to Prof. Clementi, Department of Pharmacology, University of Milano, via Vanvitelli, 32, 20129 Milan, Italy.

Accepted for publication May 2, 1983.






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