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NEUROLOGY 1984;34:182
© 1984 American Academy of Neurology

Biochemical and clinical effects of {gamma}-vinyl GABA in patients with epilepsy

Paul J. Schechter, MD, PhD, N.F.J. Hanke, MD, Jeffrey Grove, PhD, Norman Huebert, PhD and Albert Sjoerdsma, MD, PhD

From the Centre de Recherche Merrell International (Drs. Schechter, Grove, Huebert, and Sjoerdsma) 'mtstrasbourg, France, and Alexander van der Leeuw Klinik (Dr. Hanke), Amsterdam, the Netherlands.

Article abstract-In a pilot single-blind study, {gamma}-vinyl GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase (GABA-T), was administered orally to 10 epileptic patients who were refractory to conventional anticonvulsant therapy. Daily doses of 1 g and 2 g for 2 weeks each as add-on therapy were followed by 2 weeks of placebo treatment. CSF obtained from suboccipital and lumbar punctures demonstrated dose-related increases in concentrations of free and total GABA and homocarnosine with treatment, but no changes in 5-hydroxyindoleacetic acid or homovanillic acid levels, indicating effective and selective CNS GABA-T inhibition. These biochemical changes were associated with decreased seizure frequency in seven patients, decreased seizure severity in one, no change in one, and possible worsening in one. {gamma}-Vinyl GABA may be useful in the therapy of epilepsy.

Address correspondence and reprint request to Dr Schechter, Centre de Recherche Merrell International, 16, rue d'Ankara, 67084 Strasbourg Cedex, France.

Accepted for publication May 3, 1982.




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[Abstract] [Full Text] [PDF]


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