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Myasthenia gravis

Prolonged treatment with steroids

From the Department of Neurology (Drs. Sghirlanzoni and Peluchetti), the Intensive Care Unit (Dr. Fiacchino), and the Neuromuscular Research Center (Drs. Mantegazza and Cornelio), Istituto Neurologico "C. Besta," Milan, Italy.

We have evaluated chronic corticosteroid treatment in 60 myasthenic patients; 92% were followed for more than 3 years and 82% longer than 4 years. Improvement was noted in 72% of the patients. The best results were seen in those whose symptoms started after the age of 40 years. There was a correlation between the starting dose of prednisone and the rate of improvement. Complete withdrawal of steroids was possible only for 3 patients.

Address correspondence and reprint requests to Dr. Cornelio, Neuromuscular Research Center, Istituto Neurologico "C. Besta," via Celoria 11,20133 Milan, Italy.

Accepted for publication, May 24, 1989.

This article has been cited by other articles:

				M. E. Gilbert, E. A. De Sousa, and P. J. Savino Ocular Myasthenia Gravis Treatment: The Case Against Prednisone Therapy and Thymectomy Arch Neurol, December 1, 2007; 64(12): 1790 - 1792. [Full Text] [PDF]