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NEUROLOGY 1984;34:1615
© 1984 American Academy of Neurology

Immunomodulation of relapsing experimental allergic encephalomyelitis

Fred D. Lublin, MD

From the Departments of Neurology and Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.

Mice immunized to produce relapsing experimental allergic encephalomyelitis (R-EAE) were treated with immunomodulating agents known to affect acute monophasic experimental allergic encephalomyelitis. Pretreatment with either mouse spinal cord or myelin basic protein in incomplete Freund's adjuvant decreased the incidence of R-EAE from 77% to 28 and 31%, respectively. Single doses of cyclophosphamide (CY) at the time of immunization did not affect development of R-EAE. CY given repetitively in low doses decreased the incidence of R-EAE to 10%. Therefore, R-EAE can be altered by immunomodulation, but the patterns differ from those seen in acute EAE.

Address correspondence and reprint requests to Dr. Lublin, Departments of Neurology and Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19004.

Supported by National Multiple Sclerosis Society Grant RG 1363A and National Institute of Neurological and Communicative Disorders and Stroke Teacher-Investigator Development Award NS 00271.

This work was presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Accepted far publication March 27, 1984.






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