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NEUROLOGY 1984;34:1609
© 1984 American Academy of Neurology

Pharmacologic effects of L-dopa are not closely linked temporally to striatal dopamine concentration

Selden E. Spencer, MD and G. Frederick Wooten, MD

From the Departments of Neurology and Pharmacology, Division of Clinical Neuropharmacology. Washington University School of Medicine, St. Louis, MO.

In an attempt to gain insight into the mechanism of the "long-term response" to L-dopa in parkinsonians, we studied the temporal relationship between turning behavior and striatal dopamine (DA) levels after L-dopa administration to rats with unilateral nigral lesions. Turning behavior peaked at 30 minutes (9.0 ± 1.5 turns per rat per minute), diminished in intensity, reached a new peak (10.8 ± 1) at 3 hours, and persisted for 280 minutes after L-dopa administration. In contrast, dopamine levels in the striatum ipsilateral to the lesion peaked at 20 minutes and returned to control levels by 90 minutes after L-dopa administration. These data suggest that behaviors elicited by an increase in brain (striatal) dopamine levels may persist long after the dopamine concentration has returned to control levels.

Address correspondence and reprint requests to Dr. Wooten, Department of Neurology, Box 394, University of Virginia Medical Center, Charlottesville. VA 22908.

This work was supported by grants from the Institute for Medical Education and Research of the City of St. Louis, NIH-NINCDS Grant NS-14834, and the American Parkinson Disease Association.

Accepted for publication March 26, 1984.






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