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Gm allotypes in Finnish myasthenia gravis patients

From the Department of Clinical Immunology (Drs. Smith and Hammarström), Huddinge University Hospital, Huddinge, and Department of Immunobiology, Wallenberglaboratory, Karolinska Institute, Stockholm; the Department of Medical Microbiology (Dr. Grubb), Lund; and Myasthenia Gravis Center (Dr. Pirskanen), South Hospital, Stockholm, Sweden.

Gm phenotype Glm 1,2, and 3 frequencies were examined in 103 Finnish myasthenia gravis patients. There were no significant differences as compared with the expected frequency, either in the total material or when patients were subdivided according to sex, age of onset of disease, thymus pathology, or presence of HLA-B8. However, individuals with Gm(+1) had a significantly higher concentration of antibodies against acetylcholine receptor, possibly indicating a correlation with severity of disease.

Address correspondence and reprint requests to Dr. Smith, Department of Clinical Immunology, F 79, Huddinge University Hospital, S-141 86 Huddinge, Sweden.

This work was supported by the Swedish Medical Research Council, the Längman Culture Foundation, and the MS Foundation.

Accepted for publication April 2, 1984.