Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koerber, R. K.
Right arrow Articles by Case, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koerber, R. K.
Right arrow Articles by Case, M.
NEUROLOGY 1984;34:1597
© 1984 American Academy of Neurology

Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in Kleine-Levin syndrome

Rodney K. Koerber, MD, Richard Torkelson, MD, Guy Haven, MD, PhD, John Donaldson, MD, Samuel M. Cohen, MD, PhD and Mary Case, MD

From the Departments of Pathology & Laboratory Medicine (Drs. Koerber, Haven, Cohen. and Case), Pediatric Neurology (Dr. Torkelson), and Psychiatry (Dr. Donaldson), University of Nebraska Medical Center, Omaha, NE.

A 17-year-old man with the Kleine-Levin syndrome died unexpectedly of cardiopulmonary arrest during a period of autonomic instability that followed an episode of megaphagia. At autopsy, the only pertinent finding was mild depigmentation of the locus ceruleus and sub-stantia nigra. Premortem CSF levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels were elevated. These findings I indicate that many symptoms of the Kleine-Levin syndrome are a result of a neurotransmitter imbalance in the serotonergic pathway of the brainstem.

Address correspondence and reprint requests to Dr. Koerber, Department of Pathology. Memorial Hospital of Dodge County. 23rd and Clarkson, Fremont. NE 68025.

Accepted for publication March 22, 1984.




This article has been cited by other articles:


Home page
 NeurologyHome page
Y.-S. Huang, Y.-H. Lin, and C. Guilleminault
Polysomnography in Kleine-Levin syndrome
Neurology, March 4, 2008; 70(10): 795 - 801.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. Arnulf, J. M. Zeitzer, J. File, N. Farber, and E. Mignot
Kleine-Levin syndrome: a systematic review of 186 cases in the literature
Brain, December 1, 2005; 128(12): 2763 - 2776.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
S. S. Papacostas
Photosensitivity During the Hypersomnic Phase in a Patient With Kleine-Levin Syndrome
J Child Neurol, June 1, 2003; 18(6): 432 - 433.
[Abstract] [PDF]

Home page
 NeurologyHome page
Y. Dauvilliers, G. Mayer, M. Lecendreux, E. Neidhart, R. Peraita-Adrados, K. Sonka, M. Billiard, and M. Tafti
Kleine-Levin syndrome: An autoimmune hypothesis based on clinical and genetic analyses
Neurology, December 10, 2002; 59(11): 1739 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 PsychosomaticsHome page
S. Janicki, K. Franco, and R. Zarko
A Case Report of Kleine-Levin Syndrome in an Adolescent Girl
Psychosomatics, August 1, 2001; 42(4): 350 - 352.
[Full Text] [PDF]

Home page
 NeurologyHome page
K. Johkura, O. Hasegawa, and Y. Kuroiwa
Episodic encephalopathy with dilated pupils
Neurology, April 24, 2001; 56(8): 1115 - 1116.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by AAN Enterprises, Inc.