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NEUROLOGY 1984;34:1582
© 1984 American Academy of Neurology

Drug-induced seizures

A 10-year experience

Robert O. Messing, MD, Richard G. Closson, PharMD and Roger P. Simon, MD

From the Department of Neurology, School of Medicine, and the Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco.

Of 53 patients with drug-induced seizures seen in the last decade, 45% had single seizures, 40% had multiple convulsions, and 15% had status epilepticus. Generalized seizures with focal features were common, but simple partial (motor) seizures occurred in only two patients. Isoniazid, insulin, lidocaine, and psychotropic medications were the most common drugs that caused seizures. Forty-nine patients recovered without ill effects, but 4 patients died of cardiovascular complications. The combined cardiovascular toxicity of the convulsants, antidotes, and anticonvulsants was more important than the number or duration of seizures in determining outcome.

Address correspondence and reprint requests to Dr. Messing, Neurology Service, 4M62, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Accepted for publication April 3, 1984.




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