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Neurologic disorder of vitamin E deficiency in acquired intestinal malabsorption

From the Department of Neuro1ogy (Dr. Weder), Kantonsspital, St. Gallen; the Department of Neurology (Drs. Meienberg and Meier), University of Berne; and the Department of Pathology (Prof. Wildi), University of Geneva, Switzerland.

Fifteen years after onset of a malabsorption syndrome a 49-year-old man had sensory and ocuolomotor disorder with marked vitamin E deficiency. After 6 months of treatment with high parenteral doses of vitamin E, the neurologic signs slowly receded, but the patient died of gastrointestinal hemorrhage. Autopsy and sural nerve biopsy showed the changes in both central and peripheral nerves; these changes are considered characteristic of vitamin E deficiency.

Address correspondence and reprint requests to Dr. Weder, Klinik für Neurologie, Kantonsspital, 9007 St. Gallen, Switzerland.

Accepted for publication March 22,1984.