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Genetic linkage analysis in primary torsion dystonia

From the Dystonia Clinical Research Center, Department of Neurology (Drs. Bressman and Fahn) and Department of Pathology (Dr. Suciu-Foca), Columbia University College of Physicians and Surgeons; and the Laboratories for Population Genetics (Dr. Falk) and Genetics Services (Dr. Allen), New York Blood Center, New York.

We studied five families, each containing two siblings affected with torsion dystonia and having phenotypically normal parents, for linkage of dystonia to 18 marker systems, including HLA. Analysis assumed an autosomal recessive mode of inheritance. Linkage was not found. Two markers, HLA and MN, were excluded from tight linkage, and evidence against tight linkage to ABO, Rh, GC, and GLO was obtained.

Address correspondence and reprint requests to Dr. Bressman, Columbia University, College of Physicians and Surgeons, 710 West 168th Street, New York, NY 10032.

Supported by the Dystonia Medical Research Foundation. Dr. Falk is supported by grant GM 29177, National Institutes of Health.

Accepted for publication March 16, 1984.

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