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Increase of valproate-induced hyperammonemia in normal subjects by carbohydrate intake

From the Groupe de Recherche de Physiopathologie Nerveuse (Drs. Warter, Marescaux, Rumhach, Micheletti, Reitzer, and Hirsch), Clinique Neurologique, Hôpital Civil, and the Service de Médecine Interne (Drs. Chabrier and Imler), Hôpital de Hautepierre, Strasbourg, France.

Sodium valproate-induced hyperammonemia in normal subjects is increased by the intake of carbohydrates-rapidly or slowly absorbed sugars, given by mouth or IV injection. The hyperammonemia is maximal about 3 hours after carbohydrate administration. This relation between carbohydrate and ammonia metabolism has not been described previously.

Address correspondence and reprint requests to Dr. Marescaux, Clinique Neurologique, Hôpital Civil, 67091 Strasbourg Cédex, France.

Accepted for publication March 22, 1984.

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