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Mitochondrial encephalomyopathy

Fluctuating symptoms and CT

From Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.

We describe a 29-year-old man with mitochondrial encephalomyopathy. The patient's disorder was characterized by lactic acidosis, hemiparesis, seizures, aphasia, and hemianopia. CT revealed low-density areas that corresponded to the symptoms. His 56-year-old mother is also involved subclinically, demonstrating that muscle biopsy is an important requisite in the final determination of a familial inheritance pattern in mitochondrial myopathy. Neuronal mitochondrial disorders are suggested as the pathogenesis of his neurologic symptoms.

Address correspondence and reprint requests to Dr. Yamamoto, Department of Neurology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo 113, Japan.

Accepted for publication March 8, 1984.

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