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Prostacyclin infusion in acute cerebral infarction

From Oregon Health Sciences University, Portland, OR.

We gave prostacyclin infusions to seven patients with acute cerebral infarction. Patients without CT evidence of infarction improved, but those who already had hypodensities on CT did not benefit. Increased platelet activity, measured by plasma beta-thromboglobulin, decreased significantly (p < 0.01) during prostacyclin administration to normal levels, but rose again after the infusion. These results indicate that prostacyclin can be given safely in doses adequate to suppress platelet function. Our findings encouraged us to proceed with a controlled trial of its clinical efficacy.

Address correspondence and reprint requests to Dr. Miller, Northwestern University, Medical School, 303 E. Chicago Avenue, Chicago, IL 60611.

This work was supported by NIH grant no. 5 PO1 NS-17493.

Accepted for publication March 7, 1984.

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