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NEUROLOGY 1984;34:1403
© 1984 American Academy of Neurology

Myocardial infarction and stroke

Mark S. Komrad, MD, C. Edward Coffey, MD, Kathleen S. Coffey, BS, Ray McKinnis, PhD, E. Wayne Massey, MD and Robert M. Califf, MD

From the Department of Medicine, Divisions of Cardiology and Neurology, Duke University Medical Center, Durham, NC.

We used a computer data bank to evaluate 740 consecutive patients admitted to a cardiac care unit with myocardial infarction. Stroke occurred in 18 (2.4%) patients in the hospital; the anterior circulation was involved in 76% of strokes. Hospital mortality was 61% in patients with stroke and 13% in patients without stroke. Atrial arrhythmia was a significant (p 5 0.03) risk factor for stroke, but peak creatine kinase and ventricular arrhythmia were not. Cardiac pump failure, apical or anterior-lateral myocardial infarction, and history of previous stroke were associated with an increased risk of stroke. Clinical and pathologic data suggested an embolic etiology for most strokes that complicate acute myocardial infarction.

Address correspondence and reprint requests to Dr. Coffey, Box 3903, Duke Medical Center, Durham, NC 27710.

Supported by Contract HRA 230-76-0300 and Research Grants HS-03834 and HS-048473 from the National Center for Health Services Research-OASH; Research Grant HL-17670 from the National Heart, Lung and Blood Institute; Training Grant LM-07003 and Grants LM-03373 and LM-00042 from the National Library of Medicine; and Grants from the Prudential Insurance Company of America, the Kaiser Family Foundation, and the Andrew W. Mellon Foundation.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego, CA, April 28, 1983.

Accepted for publication March 8, 1984.




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