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NEUROLOGY 1984;34:89
© 1984 American Academy of Neurology

Visual evoked potentials altered by serum IgG of patients with multiple sclerosis

Arthur D. Rosen, MD, Max I. Hamburger, MD, Berhane Ghebrehiwet, DVM and Gene Gerardi, MD

From the Departments of Neurology and Medicine, School of Medicine, State University of New York, Stony Brook, NY.

Immunoglobulin G, isolated from serum of patients with multiple sclerosis was repeatedly injected into guinea pigs and serial visual evoked potentials were recorded. Latency changes indicated a reversible delay in conduction velocity in the central visual pathways. This finding suggests that some component of immunoglobulin plays a role in the pathogenesis of multiple sclerosis.

Address correspondence and reprint requests to Dr. Rosen, Department of Neurology, Health Sciences Center, State University of New York, Stony Brook, NY 11794.

Accepted for publication April 13, 1983.







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