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NEUROLOGY 1984;34:86
© 1984 American Academy of Neurology

Devic's syndrome

Antibody to glial fibrillary acidic protein in cerebrospinal fluid

C.-H. Jen Chou, PhD, Frank C.-H. Chou, PhD, W. W. Tourtellotte, MD and Robert F. Kibler, MD

From the Department of Neurology (Drs. Chous and Kibler), Emory University, Atlanta, GA, and Department of Neurology (Dr. Tourtellotte), Wadsaorth Veterans Administration Hospital, Los Angeles, CA.

The cerebrospinal fluid of a patient with Devic's syndrome contained antiglial fibrillary acidic protein antibody. The serum level of antibody was less than that in cerebrospinal fluid, and the antibody was probably synthesized within the central nervous system. Similar antibody was not found in another patient with Devic's syndrome or in patients with multiple sclerosis. The role of the antibody in the patient's illness is uncertain, but is one of the few instances in which antibody against a specific brain antigen has been described in human demyelinating disease.

Address correspondence and reprint requests to Dr. C.-H. Jen Chou, Department of neurology, Emory University, P.O. Drawer V, Atlanta, GA 30322.

Supported bv NMSS grant RG 1272 A 15.

Accepted for publication April 26, 1983.




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J. -C. Antoine, J. -P. Camdessanche, L. Absi, F. Lassabliere, and L. Feasson
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