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Phenytoin binding and renal transplantation

From the Department of Neurology (Dr. Kang), University of Wisconsin Medical School, Madison, WI, and the Department of Neurology (Dr. Leppik), University of Minnesota Medical School, Minneapolis, MN.

Limited data are available on the effect of renal transplantation on the abnormal phenytoin (PHT) binding found in uremic patients. We studied PHT binding before and after transplantation in eight patients. Return of PHT binding to normal correlated well with recovery of renal function. Correlations with serum albumin and free fatty acid levels were also studied.

Address correspondence and reprint requests to Dr. Kang, Department of Neurology, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792.

Supported by NINCDS contract #NOI-NS-5-2327.

Presented in part at the thirty-third annual meeting of the American Académy of Neurology, Toronto, Ontario, Canada, May 1981.

Accepted for publication April 26, 1983.