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Spontaneous periodic hypothermia

From the Nedroendocrine Research Laboratory and the Departments of Neurology and Radiology, Veterans Administration Medical Center; and the Departments of neurology and Medicine, University of Minnesota, Minneapolis, MN.

We studied a patient with spontaneous periodic hypothermia, agenesis of corpus callosum (Shapiro's syndrome), polydipsia, polyuria, and hyponatremia. Endocrine evaluation of hypothalamic-pituitary unit, thyroid, adrenals and gonads was normal. Results of a water deprivation test implied primary polydipsia. Four of 10 reported cases of Shapiro's syndrome had abnormalities in water metabolism. In view of the known effects of arginine vasopressin in thermoregulation, the recurrent hypothermia of this syndrome and the abnormalities of water metabolism may have a common pathogenetic mechanism.

Address correspondence and reprint requests to Dr. Morlely, Neuroen docrine Research Laboratory (1llG), VA Medical Center, 54th St. & 48th Ave. S., Minneapolls, MN 55417. Supported in part the NIH Training Grant AMO 7203.

Accepted for publication April 18, 1983.

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