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NEUROLOGY 1984;34:66
© 1984 American Academy of Neurology

Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis

Sonia Berrih, Evelyne Morel, Cyril Gaud, Francoise Raimond, Henri Le Brigand and Jean-Francois Bach

From the Centre Chirurgical Marie Lannelongue (Drs. Berrih, Gaud, and Le Brigand) and INSERM U25, Hôpital Necker (Drs. Morel, Raimond, and Bach), Paris.

The relationship between the titers of antibody against acetylcholine receptor (AChR) and T helper/ suppressor balance (assessed by the OKT4/OKT8 ratio) were investigated in 74 patieqts with myasthenia gravis (MG). All patients with elevated AChR antibody titers (> 100 nM) had hyperplastic thymuses, while most patients with low or negative antibody titers (> 1 nM) had involuted thymuses. All patients with thymoma had positive, though not very high, antibody titers. No correlation was found between anti-AChR antibody levels and OKT4/OKT8 ratios except for patients with thymoma. Thus, it appears that AChR antibody titers are more closely related to thymic pathology than to peripheral T cell imbalance. These results are consistent with the hypothesis giving a central role to thymic lymphocytes in the AChR antibody production, either as antibody producer B cells or helper T cells.

Address correspondence and reprint requests to Dr. Berrih, Centre Chirurgical Marie Lannelongue, 133 Avenue de la Résistance, 92350 Le Plessis Robinson, France.

This work was supported by INSERM CRL 80-6008 and CRL 80-6025.

Accepted for publication April 19, 1983.




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