HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wood, J. H. Articles by Golden, M. A. Search for Related Content PubMed PubMed Citation Articles by Wood, J. H. Articles by Golden, M. A.

Correlative aspects of hypervolemic hernodilution

Low-molecular-weight dextran infusions after experimental cerebral arterial occlusion

From the Division of Neurosurgery (Dr. Wood), Emory University Clinic, Atlanta, Georgia and the Division of Neurosurgery (Drs. Simeone, Fink, and Golden), Pennsylvania Hospital, University of Pennsylvania School of Medicine, Philadelpia, PA.

Unilateral clipping of cerebral arteries in eight dogs reduced regional cortical blood flow (rCoBF) without altering cardiac output (CO) or intracranial pressure (ICP) and resulted in 10% hemispheric infarction. In ten dogs, total blood volume (TBV), CO, rCoBF in the region of the occluded artery, and ICP increased while the hematocrit (Hct) decreased following two low-molecular-weight dextran (D40) infusions. Hemispheric infarction was 4%. The CO, rCoBF, and ICP correlated directly with TBV, but inversely with Hct, while rCoBF correlated positively with CO.

Two similar hemodiluting D40 infusions in nine control dogs raised TBV, CO, and ICP but not rCoBF. The CO, rCoBF, and ICP correlated positively with TBV but inversely with Hct while rCoBF correlated with CO.

Thus, hypervolemic hemodilution with D40 enhances collateral perfusion to acutely ischemic regions of brain distal to segmental arterial occlusions and concomitantly augments CO and ICP. Correlations between CO and cerebral blood flow after D40 infusion may be secondary to lowered Hct.

Address correspondence and reprint requests to Dr. Wood, Division of Neurosurgery, Emory University Clinic, 1365 Clifton Road, NE, Atlanta, Georgia 30322.

This paper was presented in part at the thirty-third annual meeting of the American Academy of Neurology, Toronto, Ontario, April, 1981 and the 10th International Symposium on Cerebral Blood Flow and Metabolism, St. Louis, Missouri, June, 1981.

Accepted for publication April 26, 1983.

This article has been cited by other articles:

				Y. Izumi, Y. Tsuda, S.-I. Ichihara, T. Takahashi, and H. Matsuo Effects of Defibrination on Hemorheology, Cerebral Blood Flow Velocity, and CO2 Reactivity During Hypocapnia in Normal Subjects Stroke, August 1, 1996; 27(8): 1328 - 1332. [Abstract] [Full Text]

				Y.-K. Tu and H.-M. Liu Effects of Isovolemic Hemodilution on Hemodynamics, Cerebral Perfusion, and Cerebral Vascular Reactivity Stroke, March 1, 1996; 27(3): 441 - 445. [Abstract] [Full Text]

				J. H. Wood and D. B. Kee JR Analytic Reviews : Hypervolemic Hemodilution in Acute Ischemic Stroke J Intensive Care Med, May 1, 1987; 2(3): 126 - 136. [Abstract] [PDF]

				M. Yamamoto Effects of Fibrinogen, Globulin, Albumin and Hematocrit on the Kinetics of Erythrocyte Aggregation in Man Angiology, August 1, 1986; 37(9): 663 - 671. [Abstract] [PDF]