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NEUROLOGY 1984;34:102
© 1984 American Academy of Neurology

Cerebrospinal fluid monoamine metabolites in patients with infantile spasms

Faye Silverstein, MDCM and Michael V. Johnston, MD

From the Departments of Pediatrics and Neurology, University of Michigan Medical School, and Center for Human Growth and Development, Ann Arbor, MI.

We measured CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) by high-performance liquid chromatography in seven children with infantile spasms and in a group of age-and sex-matched controls. The mean concentration of the serotonin metabolite 5-HIAA was 40% (p < 0.01) lower in the infantile spasms group as compared with controls; HVA levels were similar in both groups. The data provide additional evidence that serotonin metabolism is abnormal inpatients with infantile spasms.

Address correspondence and reprint requests to Dr. Johnston, 1013 Neuroscience Building, 1103 East Huron Street, The University of Michigan, Ann Arbor, MI 48109.

Accepted for publication April 13, 1983.




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