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NEUROLOGY 1983;33:1219
© 1983 American Academy of Neurology

Visual evoked potentials and long latency event-related potentials in chronic renal failure

Stanley N. Cohen, MD, Karl Syndulko, PhD, Barbara Rever, MD, Jeffrey Kraut, MD, Jack Coburn, MD and Wallace W. Tourtellotte, MD, PhD

Neurology (Drs. Cohen and Syndulko), Nephrulogy (Drs. Rever, Kraut, and Coburn), and Research Services (Dr. Tourtellotte), VA Medical Cente—-West Los Angeles, Wadsworth Division; and the Departments of Neurology and Medicine, University of California at Los Angeles, School of Medicine, Los Angeles, California.

We studied auditory event-related potentials elicited in a target detection paradigm (P300 and pattern shift visual evoked potentials (PVEPs) in 22 patients with chronic renal failure and no clinical evidence of cognitive or visual impairment. Thirteen patients were maintained on chronic hemodialysis, and 9 patients were receiving a low-protein diet. Thirty-three percent of patients receiving the low-protein diet and 58% of the dialysis patients had abnormal P300 latencies. Most patients tested had abnormal PVEP. Four hemodialysis patients had elevated serum parathyroid hormone (PTH) levels, and 9 had normal or slightly elevated values. P300 and PVEP latencies were abnormal in both groups. These observations indicate that elevated PTH levels are not solely responsible for the abnormalities in all patients. P300 and PVEP may be valuable in evaluating neuronal dysfunction in the patient with chronic renal failure.

Address correspondence and reprint requests to Dr. Cohen, Neurology Service (W127), VA Medical Center—West Los Angeles, Los Angeles, CA 90073.

Accepted for publication January 26, 1983.






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