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NEUROLOGY 1983;33:1209
© 1983 American Academy of Neurology

Myasthenia gravis associated with Satoyoshi syndrome

Muscle cramps, alopecia, and diarrhea

Akira Satoh, MD, Mitsuhiro Tsujihata, MD, Toshiro Yoshimura, MD, Masataka Mori, MD and Shigenobu Nagataki, MD

First Department of Internal Medicine, School of Medicine, Nagasaki University. Sakamoto-machi 7–1, Nagasaki, Japan.

We studied a woman who had evidence of myasthenia gravis at age 17. At age 19, she gradually developed alopecia and painful muscle spasms (Satoyoshi disease). Deposition of immune complexes (IgG, C3, and C9) was demonstrated at the motor endplates of limb muscle (biceps brachii); primary synaptic clefts were widened, and postsynaptic folds were simplified. This is the first case of myasthenia and Satoyoshi disease in the same patient.

Address correspondence and reprint requests to Dr. Satoh, First Department of Internal Medicine, School of Medicine, Nagasaki University, Sakamoto-machi 7–1, Nagasaki, Japan.

Accepted for publication December 17, 1982




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