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In vitro erythrocyte water transport in Duchenne muscular dystrophy

An NMR investigation

Department of Chemistry, Emory University, Atlanta, GA.

Previous nuclear magnetic resonance (NMR) studies of erythrocyte water transport in Duchenne muscular dystrophy (DMD) have been extended to include mothers, as well as a larger patient group. The results, reported as values of the mean residence time, _a, of intracellular water, reveals an experimentally significant decrease in permeability to water in most of the patients and one-half of the mothers examined. It was found that all mothers of patients with normal _a values also show normal results. This finding suggests that Duchenne muscular dystrophy may exhibit genetic heterogeneity.

Address correspondence and reprint requests to Dr. Ashley, Department of Chemistry, Emory University, Atlanta, GA 30322.

This research was supported in part by NIH grants Nos. GM-10848 and RR39.

Accepted for publication January 6, 1983.

This article has been cited by other articles:

				J. L. Anderson, S. I. Head, C. Rae, and J. W. Morley Brain function in Duchenne muscular dystrophy Brain, January 1, 2002; 125(1): 4 - 13. [Abstract] [Full Text] [PDF]