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A longitudinal study of speech fluency in aphasia

CT correlates of recovery and persistent nonfluency

Department of Neurology, University of Minnesota (Drs. Knopman, Selnes, Niccum, and Rubens), Minneapolis, MN, and the Department of Radiology (Drs. Yock and Larson), Hennepin County Medical Center, Minneapolis.

The anatomic correlates of speech fluency were studied in 54 right-handed patients with aphasia due to stroke. Speech fluency was assessed at 1 month postonset and then monthly for 5 months. CTs obtained at 5 months postonset were used for lesion localization and volume determination. Persistent nonfluency was associated with lesions in the rolandic cortical region and underlying white matter. Recovery from nonfluency occurred in 6 of 27 patients. Lesions in these six patients were less extensive than lesions in patients with persistent nonfluency. Patients who were fluent by 1 month lacked extensive rolandic lesions.

Address correspondence and reprint requests to Dr. Knopman, Department of Neurology, Box 295, University Hospitals, Minneapolis, MN 55455.

This research was supported by NINCDS contract #N01-NS-2378.

A preliminary version of this paper was presented at the twentieth annual meeting of the Academy of Aphasia, New Paltz, NY, October 1982.

Accepted for publication January 18, 1983.

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